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Functional / Structural Data: Variant Annotations and Phenotypes

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Functional/structural data in TP53 with their annotations (includes validated polymorphisms)
Functional assessment of p53 mutant proteins in various experimental assays
Systematic functional assessment of p53 mutant proteins in yeast assays

Somatic Variants

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Somatic variants in human tumor samples (data file)
Somatic variants in human tumor samples (references file)
Prevalence of somatic variants by tumor site
Prevalence of the R249S TP53 variants in liver cancer
Prognostic value of somatic variants

Germline Variants

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TP53 germline variants and family history (data file)
TP53 germline variants and family history (references file)
TP53 germline variants prevalence in selected cohorts
Frequency of individual variants in case-controls series (new dataset under development)

Cell Lines

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TP53 variant status of human cell-lines

Mouse-Models

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Mouse models with engineered TP53

Experimentally Induced Variants

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Variants induced in experimental models of mutagenesis
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