Other Resources

Variant Nomenclatures

The genomic reference sequence used for annotating TP53 variants is NC_000017.11 (hg38 build) from GenBank.
Variants are reported according to HGVS nomenclature recommendations.
We recommend to use Mutalyzer, to help you format your variant data according to HGVS guidelines and to convert positions between different genome build or isoforms.

Protocols and Tools


To assess TP53 variant status it is recommended to perform gene sequencing of all exons, including the splice junctions and completed with MLPA to detect large deletion/duplications. Immuno-histochemical analysis is not a good method for assessing TP53 variant status, as it cannot distinguish between the various types of variants, does not detect truncating variants (false-negative results), and gives false-positive results (over-expressed WT protein).
Some Example of Sequencing Protocols:

Other tools

3D Structures Analysis

3D Viewer

Use mouse or control buttons (located on the right) to explore.

Structural Impacts of Variants

Other Databases

TP53 databases

There are several links to different TP53 databases available on the web. Several resources are not updated anymore and may contain obsolete data. It is recommended to use up-to-date resources.

Related Databases


p53 in the Clinics: Book Cover

p53 in the Clinics

With over 60,000 referenced publications, p53 has emerged as one of the most important factors in human cancer. Research on p53 has led to a complete overhaul of our understanding of the molecular basis of human cancer.

25 Years of p53 Research

The discovery of p53 in 1979 marks the beginning of a most fascinating era of modern cancer research and molecular biology, an era that is still in full swing and does not show any signs of ending in the foreseeable future.