Prognostic Value of Somatic Variants

Summary results may be found in the reviews and table below:
  • TP53 somatic variants: prognostic and predicitve value in human cancers. Olivier M. Chapter 8 in p53 in the Clinics.
    Hainaut, Pierre; Olivier, Magali; Wiman, Klas (Eds.) 2013, VII, 544 p. 45 illus., Hardcover ISBN 978-1-4614-3675-1 Jan;2(1):a001008.
  • TP53 mutations in human cancers: origins, consequences, and clinical use. Olivier M, Hollstein M, Hainaut P. Cold Spring Harb Perspect Biol 2010 Jan;2(1):a001008. PubMed
Tumor Site Number of studies* reporting that TP53 mutations are:
Related to Bad Prognosis Related to Good Prognosis Not Related to Prognosis
Bladder 4 - 3
Bones 1 - 1
Brain 3 2 4
Breast 28 1 5
Colorectum 16 - 8
Esophagus 2 - 2
Head & Neck 7 - 2
Hematol. 12 - -
Larynx - - 1
Liver 3 - -
Lung 8 - 6
Ovary 7 1 2
Pancreas 1 1 1
Prostate 1 - 1
Soft Tissues 2 - -
Stomach 1 - 2
Renal Pelvis 1 - -
* Only studies with >50 cases were included.
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